Pseudomonas fluorescens strain 2-79, a natural isolate of the rhizosphere of wheat (Triticum aestivum L.), possesses antagonistic potential toward several fungal pathogens. We report the draft genome sequence of strain 2-79, which comprises 5,674 protein-coding sequences. FOOTNOTES Address correspondence to Gerhard H. Braus, gbraus{at}gwdg.de. Citation Nesemann K, Braus-Stromeyer SA, Thuermer A, Daniel R, Mavrodi DV, Thomashow LS, Weller DM, Braus GH. 2015. Draft genome sequence of the phenazine-producing Pseudomonas fluorescens strain 2-79. Genome Announc 3(2):e00130-15. doi:10.1128/genomeA.00130-15. Received 4 February 2015. Accepted 18 February 2015. Published 26 March 2015. Copyright © 2015 Nesemann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.