Background- Information on lifestyle factors (eg. coffee /tea drinking, smoking) and Parkinson’s Disease(PD) in South Asia is limited. The objective of this study was to determine associations between lifestyle factors and PD in a clinic-based study in Sri Lanka. Methods–Demographic and lifestyle factor data was collected from an unselected cohort of PD patients and age and gender-matched controls attending clinics in Greater Colombo, Sri Lanka. Findings–Of 229 patients with parkinsonism, 144 had Idiopathic PD. Controls numbered 102. Coffee drinkers and smokers were significantly less likely to have PD (coffee, p<0.001; OR=0.264; smoking, p=0.043; OR=0.394). Coffee drinkers were older at PD onset(p<0.001). Similar trends seen with tea drinking were not statistically significant. Conclusions -This is the first formal study of PD and these lifestyle factors in South Asia. It demonstrates an association between coffee drinking, smoking and a decreased prevalence of PD, and coffee drinking and later age of PD onset. This is in line with other studies done worldwide, suggesting biological associations with global relevance.