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Georg Thieme Verlag, Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 14(28), p. 1753-1757

DOI: 10.1055/s-0036-1589092

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A One-Pot Methodology for the Synthesis of the Yohimban Skeleton

Journal article published in 2017 by Claudio Parra, Josep Bonjoch ORCID, Pablo Solís, Ben Bradshaw ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A simple and straightforward assembly of the yohimban skeleton was achieved by condensation of an acyclic β-keto ester with tryptamine, followed by consecutive cross metathesis and tandem cyclization reactions, leading to the formation of three new rings. The whole process was readily carried out in the one-flask providing a rapid entry to the pentacyclic scaffold of yohimbine alkaloids.