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Rockefeller University Press, Journal of Cell Biology, 9(216), p. 2615-2618, 2017

DOI: 10.1083/jcb.201708002

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Zebrafish earns its stripes for in vivo ASC speck dynamics

Journal article published in 2017 by Jelena S. Bezbradica ORCID, Kate Schroder ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.