Published in
Taylor and Francis Group, OncoImmunology, 5(1), p. 786-788
DOI: 10.4161/onci.19750
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The emergence of phox-ER stress induced immunogenic apoptosis
Journal article published in 2012 by
Abhishek D. Garg 
,
Dmitri V. Krysko,
Peter Vandenabeele,
Patrizia Agostinis
,
Dmitri V. Krysko,
Peter Vandenabeele,
Patrizia Agostinis
This paper is made freely available by the publisher.
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Abstract
Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved “core” functions (e.g., PERK/PI3K-based modulation of secretory trafficking) rather than “private” ones (caspase-8 and eIF2α-phosphorylation) engaged by other IA inducers.