Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 27(114), p. 7073-7076, 2017
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- National Academy of Sciences
- ORCID
- [repository.cshl.edu] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
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Measuring shared variants in cohorts of discordant siblings with applications to autism
Journal article published in 2017 by
Kenny Ye 
,
Ivan Iossifov,
Dan Levy,
Boris Yamrom,
Andreas Buja,
Abba M. Krieger,
Michael Wigler
,
Ivan Iossifov,
Dan Levy,
Boris Yamrom,
Andreas Buja,
Abba M. Krieger,
Michael Wigler
This paper is made freely available by the publisher.
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Abstract
Significance We developed a statistical method that detects if shared ancestral genetic variants contribute to a disorder by analyzing common variant data from cohorts that include discordant sibling pairs. We applied this method to two published datasets of autism families and found strong evidence that shared ancestral genetic variants contribute to autism spectrum disorders.