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National Academy of Sciences, Proceedings of the National Academy of Sciences, 46(110), 2013

DOI: 10.1073/pnas.1308811110

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Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes

Journal article published in 2013 by Np P. Hoyle ORCID, D. Ish-Horowiicz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance This paper describes in vivo measurements of the kinetics of transcript processing and export for endogenous genes in mouse and chick embryos. It shows that transcript export is unexpectedly slow, even slower than splicing, and relates its finding to rate-limiting steps that would contribute to the molecular oscillator that drives segmentation in vertebrate embryos. It also relates them to interspecies differences in clock period.