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American Society for Microbiology, Journal of Virology, 5(88), p. 3039-3042, 2014

DOI: 10.1128/jvi.03222-13

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An Increase in Acid Resistance of Foot-and-Mouth Disease Virus Capsid Is Mediated by a Tyrosine Replacement of the VP2 Histidine Previously Associated with VP0 Cleavage

Journal article published in 2013 by Angela Vázquez-Calvo, Flavia Caridi, Francisco Sobrino ORCID, Miguel A. Martín-Acebes, R. M. Sandri-Goldin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The foot-and-mouth disease virus (FMDV) capsid is highly acid labile, but introduction of amino acid replacements, including an N17D change in VP1, can increase its acid resistance. Using mutant VP1 N17D as a starting point, we isolated a virus with higher acid resistance carrying an additional replacement, VP2 H145Y, in a residue highly conserved among picornaviruses, which has been proposed to be responsible for VP0 cleavage. This mutant provides an example of the multifunctionality of picornavirus capsid residues.