Taylor and Francis Group, OncoImmunology, 2(2), p. e22984
DOI: 10.4161/onci.22984
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Transcription factors of the MYC family regulate several homeostatic cell functions, and their role as proto-oncogenes has been the focus of interest for decades. We have recently demonstrated that c-MYC is expressed by tumor-associated macrophages (TAMs) and regulates their phenotype and pro-tumor activities in vivo.