Published in

Nature Research, Nature Reviews Neuroscience, 8(10), p. 549-560, 2009

DOI: 10.1038/nrn2683

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The genetic and molecular regulation of sleep: from fruit flies to humans

Journal article published in 2009 by Chiara Cirelli ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It has been known for a long time that genetic factors affect sleep quantity and quality. Genetic screens identified several mutations that affect sleep across species, pointing to an evolutionary conserved regulation of sleep. Moreover, it has also been recognized that sleep affects the expression of genes. These findings have given valuable clues about the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders.