Published in
American Society of Hematology, Blood Advances, 14(1), p. 972-979, 2017
DOI: 10.1182/bloodadvances.2017004903
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Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines
Journal article published in 2017 by
Yanyan Zhang,
Liang He,
Dorothée Selimoglu-Buet 
,
Chloe Jego,
Margot Morabito,
Christophe Willekens,
M'boyba Khadija Diop,
Patrick Gonin ,
Valérie Lapierre,
Nathalie Droin,
Eric Solary ,
Fawzia Louache
,
Chloe Jego,
Margot Morabito,
Christophe Willekens,
M'boyba Khadija Diop,
Patrick Gonin ,
Valérie Lapierre,
Nathalie Droin,
Eric Solary ,
Fawzia Louache
This paper is made freely available by the publisher.
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Abstract
Key Points Transgenic mice expressing 3 human cytokines enable expansion of CMML cells with limited stem cell engraftment. The mutational profile of CMML cells that expand in mice mirrors that of patient monocytes.