Published in
Elsevier, Journal of Allergy and Clinical Immunology, 5(131), p. 1443-1446.e1, 2013
DOI: 10.1016/j.jaci.2013.02.026
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.ncbi.nlm.nih.gov] | PDF
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Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells
Journal article published in 2013 by
Jorg van Loosdregt,
Roberto Spreafico 
,
Maura Rossetti ,
Berent J. Prakken,
Martin Lotz,
Salvatore Albani
,
Maura Rossetti ,
Berent J. Prakken,
Martin Lotz,
Salvatore Albani
This paper is available in a repository.
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Abstract
Although hydroxychloroquine is used for treatment of numerous autoimmune disorders the mechanism is unclear. We here demonstrate that hydroxychloroquine preferentially induces apoptosis of CD45RO+ memory and effector T cells by inhibiting the survival pathway of autophagy.