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Public Library of Science, PLoS ONE, 3(9), p. e91885, 2014

DOI: 10.1371/journal.pone.0091885

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In Vitro Interaction of Pseudomonas aeruginosa with Human Middle Ear Epithelial Cells

Journal article published in 2014 by Rahul Mittal, M’hamed Grati, Robert Gerring, Patricia Blackwelder ORCID, Denise Yan, Jian-Dong Li, Xue Zhong Liu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Otitis media (OM) is an inflammation of the middle ear which can be acute or chronic. Acute OM is caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis whereas Pseudomonas aeruginosa is a leading cause of chronic suppurative otitis media (CSOM). CSOM is a chronic inflammatory disorder of the middle ear characterized by infection and discharge. The survivors often suffer from hearing loss and neurological sequelae. However, no information is available regarding the interaction of P. aeruginosa with human middle ear epithelial cells (HMEECs).