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American Society of Hematology, Blood, 3(130), p. 297-309

DOI: 10.1182/blood-2016-12-756585

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CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies

Journal article published in 2017 by Mohamad F. Al Sayed ORCID, Carla A. Ruckstuhl, Tamara Hilmenyuk, Christina Claus, Jean-Pierre Bourquin ORCID, Beat C. Bornhauser ORCID, Ramin Radpour ORCID, Carsten Riether ORCID, Adrian F. Ochsenbein ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Key Points CD27 expression on malignant B cells triggers CD70 reverse signaling in NK cells and improves lymphoma immunosurveillance. CD70 reverse signaling in NK cells is mediated via the AKT signaling pathway and enhances survival and effector function.