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National Academy of Sciences, Proceedings of the National Academy of Sciences, 44(103), p. 16224-16229, 2006

DOI: 10.1073/pnas.0607640103

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Yeast mitochondrial ADP/ATP carriers are monomeric in detergents

Journal article published in 2006 by Lisa Bamber, Marilyn Harding, P. Jonathan G. Butler, P. Jonathan G. Butler, Edmund R. S. Kunji ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mitochondrial carriers are believed widely to be homodimers both in the inner membrane of the organelle and in detergents. The dimensions and molecular masses of the detergent and protein–detergent micelles were measured for yeast ADP/ATP carriers in a range of different detergents. The radius of the carrier at the midpoint of the membrane, its average radius, its Stokes' radius, its molecular mass, and its excluded volume were determined. These parameters are consistent with the known structural model of the bovine ADP/ATP carrier and they demonstrate that the yeast mitochondrial ADP/ATP carriers are monomeric in detergents. Therefore, models of substrate transport have to be considered in which the carrier operates as a monomer rather than as a dimer.