Published in
Royal Society of Chemistry, Chemical Science, 17(9), p. 4118-4123, 2018
DOI: 10.1039/c7sc05441f
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DNA-binding miniproteins based on zinc fingers. Assessment of the interaction using nanopores
Journal article published in 2018 by
Jéssica Rodríguez 
,
Soraya Learte-Aymamí,
Jesús Mosquera,
Garbiñe Celaya,
David Rodríguez-Larrea,
M. Eugenio Vázquez ,
José L. Mascareñas
,
Soraya Learte-Aymamí,
Jesús Mosquera,
Garbiñe Celaya,
David Rodríguez-Larrea,
M. Eugenio Vázquez ,
José L. Mascareñas
This paper is made freely available by the publisher.
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Abstract
We report a synthetic miniprotein that combines zinc finger modules of the transcription factor GAGA with the AT-hook peptide. This designed chimera binds to extended DNA sites with high affinity and selectivity, as shown by nanopore force spectroscopy.