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BioMed Central, BMC Medical Genetics, 1(15), 2014

DOI: 10.1186/s12881-014-0113-6

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A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival

Journal article published in 2014 by Fredrik Baecklund, Jia-Nee Foo ORCID, Paige Bracci, Hatef Darabi, Robert Karlsson, Henrik Hjalgrim, Richard Rosenquist ORCID, Hans-Olov Adami, Bengt Glimelius, Mads Melbye, Lucia Conde, Jianjun Liu, Keith Humphreys, Christine F. Skibola, Karin E. Smedby
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Survival in follicular lymphoma (FL) is highly variable, even within prognostic groups defined by tumor grade and the Follicular Lymphoma International Prognostic Index. Studies suggest that germline single nucleotide polymorphisms (SNPs) may hold prognostic information but further investigation is needed. Methods: We explored the association between SNPs and FL outcome using two approaches: 1) Two independent genome-wide association studies (GWAS) of similar to 300.000 SNPs followed by a meta-analysis encompassing 586 FL patients diagnosed in Denmark/Sweden 1999-2002 and in the United States 2001-2006; and 2) Investigation of 22 candidate-gene variants previously associated with FL outcome in the Danish/Swedish cohort (N = 373). We estimated time to lymphoma-specific death (approach 1 and 2) and lymphoma progression (approach 2) with hazard ratios (HR) and 95% confidence intervals (CI) in a multivariable Cox regression model. Results: In the GWAS meta-analysis, using a random effects model, no variants were associated with lymphoma-specific death at a genome-wide significant level (p