Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Neuroscience, 11(14), p. 1410-1412, 2011

DOI: 10.1038/nn.2952

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PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity

Journal article published in 2011 by Akio Sumioka, Travis E. Brown, Akihiko S. Kato, David S. Bredt, Julie A. Kauer ORCID, Susumu Tomita
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPA receptor (AMPAR) auxiliary subunit TARPγ-8 could be a result of a reduction in AMPAR expression or of the direct action of γ-8. We generated TARPγ-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPARs were reduced in the mutant mice, but extrasynaptic AMPAR expression and long-term potentiation (LTP) were unaltered. Our findings suggest that there are distinct TARP-dependent mechanisms for synaptic transmission and LTP.