Animal Models of Dyssynchrony

Strik, Marc; van Middendorp, Lars B.; Middendorp, Lars B.; Vernooy, Kevin

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Animal Models of Dyssynchrony

Journal article published in 2011 by Marc Strik, Lars B. van Middendorp, Lars B. Middendorp, Kevin Vernooy

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Abstract

Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.