Published in
American Society of Hematology, Blood Advances, 12(1), p. 733-747, 2017
DOI: 10.1182/bloodadvances.2017005538
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Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia
Journal article published in 2017 by
Laurent Renou,
Pierre-Yves Boelle,
Caroline Deswarte,
Salvatore Spicuglia,
Aissa Benyoucef,
Julien Calvo,
Benjamin Uzan,
Mohamed Belhocine,
Agata Cieslak 
,
Judith Landman-Parker,
Andre Baruchel,
Vahid Asnafi,
Françoise Pflumio,
Paola Ballerini,
Irina Naguibneva
,
Judith Landman-Parker,
Andre Baruchel,
Vahid Asnafi,
Françoise Pflumio,
Paola Ballerini,
Irina Naguibneva
This paper is made freely available by the publisher.
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Abstract
Key Points TLX3 transactivates LINC00478, the host gene of oncogenic miR-125b-2 in T-ALL. TLX3 and miR-125b contribute to the differentiation arrest and the expansion of transformed T cells.