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Springer Nature [academic journals on nature.com], Translational Psychiatry, 2(4), p. e358-e358, 2014

DOI: 10.1038/tp.2014.2

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Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene

Journal article published in 2014 by C. van Duijn, A. Ruiz, S. Heilmann ORCID, H. Wagner, M. Thelen, T. Becker, I. Hernández, M. Rosende-Roca, A. Mauleón, R. Sims, L. Tarraga, C. Bellenguez, J. C. Bis, O. Sotolongo-Grau, D. Harold ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio=1.31; confidence interval 95% (1.19–1.44); P=9.74 × 10−9).