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Springer (part of Springer Nature), Analytical and Bioanalytical Chemistry, 3(404), p. 731-740
DOI: 10.1007/s00216-012-6134-0
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New alkyl-phosphate bonded stationary phases for liquid chromatographic separation of biologically active compounds
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Abstract
A new type of bonded stationary phase for liquid chromatography, with the properties of immobilized artificial membranes, has been synthesized. Alkyl-phosphate adsorbents were obtained by modification of aminopropyl silica gel. The structures of the synthesized materials were confirmed by use of instrumental techniques--elemental analysis, infrared spectroscopy (FTIR), and (13)C and (29)Si CP/MAS NMR. Analysis revealed that the adsorbents mimic the phospholipids present in natural cell membranes. The new synthesized alkyl-phosphate stationary phases may be used for liquid chromatographic separation of biologically active compounds of different polarity.