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International Union of Crystallography, Acta Crystallographica Section E: Structure Reports Online, 6(65), p. o1271-o1272, 2009

DOI: 10.1107/s1600536809016997

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16α,17α-Ep­oxy-5α-hydr­oxy-6β-nitrooxy-20-oxopregnan-3β-yl acetate

Journal article published in 2009 by R. M. A. Pinto, A. Matos Beja, J. A. R. Salvador, J. A. Paixão ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The title steroid, C23H33NO8, is a pregnane derivative obtained regio-, stereo- and chemoselectively from the ring opening of the corresponding 5α,6α;16α,17α-diepoxide with bismuth(III) nitrate. There are two symmetry-independent molecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. All rings aretrans-fused. The conformations of the six-membered rings are close to chair forms, while the five-membered ring adopts an envelope conformation. The molecules are held together by an extensive O—H...O hydrogen-bonding network of chains runnning along theaaxis.