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Frontiers Media, Frontiers in Immunology, (3)

DOI: 10.3389/fimmu.2012.00371

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Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection

Journal article published in 2012 by Brendan E. Russ, Alice E. Denton ORCID, Lauren Hatton, Hayley Croom, Matthew R. Olson ORCID, Stephen J. Turner
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.