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Wiley Open Access, Journal of Diabetes Investigation, 4(5), p. 445-448, 2014

DOI: 10.1111/jdi.12182

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Factors influencing the durability of the glucose‐lowering effect of sitagliptin combined with a sulfonylurea

Journal article published in 2014 by Akira Kubota, Daisuke Yabe ORCID, Akira Kanamori, Akira Kuroe, Nobuo Takahashi, Tatsuhiko Saito, Ikuro Matsuba, Koichiro Nabe, Takeshi Kurose, Yutaka Seino
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We analyzed the changes of glycemic control over 12 months and the factors influencing blood glucose in 162 Japanese patients with type 2 diabetes having inadequate glycemic control despite sulfonylurea‐based therapy who received add‐on sitagliptin. Hemoglobin A1c (HbA1c) decreased significantly after 4 weeks of treatment, and this improvement was maintained for 1 year, although HbA1c was slightly higher in week 52 than in week 24. Comparison of the patients showing a ≥0.4% increase of HbA1c between weeks 24 and 52 (n = 57) with the others (n = 105) showed a significant difference in the change of bodyweight, as well as the dose of glibenclamide (both P