Why non-inferiority is more challenging than superiority?
Journal article published in 2017 by
Maria Pia Sormani 
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Abstract
Demonstrating non-inferiority in clinical trials is usually more challenging than showing superiority. In multiple sclerosis (MS), non-inferiority trials are rarely designed since they would require prohibitive sample sizes. In this brief report, the reasons why non-inferiority trials are usually larger than superiority trials is explored.