The 2.1 GHz radio source catalogue of the 25 deg² ultimate XMM extragalactic survey south (XXL-S) field, observed with the Australia Telescope Compact Array (ATCA), is presented. The final radio mosaic achieved a resolution of ~ 4.8″ and a median rms noise of σ ≈ 41 μJy/beam. To date, this is the largest area radio survey to reach this flux density level. A total of 6350 radio components above 5σ are included in the component catalogue, 26.4% of which are resolved. Of these components, 111 were merged together to create 48 multiple-component radio sources, resulting in a total of 6287 radio sources in the source catalogue, 25.9% of which were resolved. A survival analysis revealed that the median spectral index of the Sydney University Molonglo Sky Survey (SUMSS) 843 MHz sources in the field is α = −0.75, consistent with the values of − 0.7 to − 0.8 commonly used to characterise radio spectral energy distributions of active galactic nuclei. The 2.1 GHz and 1.4 GHz differential radio source counts are presented and compared to other 1.4 GHz radio surveys. The XXL-S source counts show good agreement with the other surveys.