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American Society for Microbiology, Genome Announcements, 4(2), 2014

DOI: 10.1128/genomea.00759-14

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Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance

Journal article published in 2014 by H. Guio, D. Tarazona, M. Galarza ORCID, V. Borda ORCID, R. Curitomay
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs , tlyA , and eis . Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.