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BMJ Publishing Group, Journal of Neurology, Neurosurgery and Psychiatry, 5(76), p. 650-655, 2005

DOI: 10.1136/jnnp.2004.047993

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Progression of structural neuropathology in preclinical Huntington's disease: a tensor based morphometry study

Journal article published in 2005 by N. Mahant, E. A. McCusker, A. J. Duggins, C. M. Kipps, L. Gomes, J. Ashburner ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Background and objectives: Regional cerebral atrophy occurs in carriers of the Huntington's disease (HD) gene mutation before clinical diagnosis is possible. The current inability to reliably measure progression of pathology in this preclinical phase impedes development of therapies to delay clinical onset. We hypothesised that longitudinal statistical imaging would detect progression of structural pathology in preclinical carriers of the HD gene mutation, in the absence of measurable clinical change.