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National Academy of Sciences, Proceedings of the National Academy of Sciences, 30(102), p. 10682-10687, 2005

DOI: 10.1073/pnas.0504662102

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Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia

Journal article published in 2005 by D. J. Hulse-Post, K. M. Sturm-Ramirez, J. Humberd, P. Seiler, Govorkova Ea, E. A. Govorkova ORCID, S. Krauss, C. Scholtissek, P. Puthavathana, C. Buranathai, T. D. Nguyen, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show that these H5N1 viruses are reverting to nonpathogenicity in ducks. Ducks experimentally infected with viruses isolated between 2003 and 2004 shed virus for an extended time (up to 17 days), during which variant viruses with low pathogenicity were selected. These results suggest that the duck has become the “Trojan horse” of Asian H5N1 influenza viruses. The ducks that are unaffected by infection with these viruses continue to circulate these viruses, presenting a pandemic threat.