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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(52), p. 4522-4525, 2008

DOI: 10.1128/aac.00448-08

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In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis

Journal article published in 2008 by Patricia M. Tavares, Karin Thevissen, Bruno P. A. Cammue, Isabelle E. J. A. Francois, Eliana Barreto-Bergter, Carlos P. Taborda ORCID, Alexandre F. Marques ORCID, Marcio L. Rodrigues, Leonardo Nimrichter ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans , inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis.