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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(52), p. 4483-4485, 2008

DOI: 10.1128/aac.00491-08

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In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus.

Journal article published in 2008 by Paul E. Verweij, D. T. A. te Dorsthorst, Debbie T. A. Te Dorsthorst, Willem H. P. Janssen, Jacques F. G. M. Meis, Johan W. Mouton ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.