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Scientific Journals, Journal of Biology, 3(9), p. 20

DOI: 10.1186/jbiol230

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Robust and specific inhibition of microRNAs in Caenorhabditis elegans

Journal article published in 2010 by Samrat T. Kundu ORCID, Frank J. Slack ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence , Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo . See research article http://www.silencejournal.com/content/1/1/9