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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(42), p. 2772-2772, 1998

DOI: 10.1128/aac.42.10.2772

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Energy-Dependent Accumulation of Fluoroquinolones in Quinolone-Resistant Klebsiella pneumoniae Strains

Journal article published in 1998 by Luis Martínez-Martínez, Isabel García, Sofía Ballesta, Vicente Javier Benedí, Santiago Hernández-Allés, Alvaro Pascual ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The intracellular accumulation of norfloxacin and pefloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.