Both observations and simulations show that major tidal interactions or mergers between gas-rich galaxies can lead to intense bursts of star formation. Yet, the average enhancement in star formation rate (SFR) in major mergers and the contribution of such events to the cosmic SFR are not well estimated. Here we use photometric redshifts, stellar masses, and UV SFRs from COMBO-17, 24 μm SFRs from Spitzer, and morphologies from two deep Hubble Space Telescope (HST) cosmological survey fields (ECDFS/GEMS and A901/STAGES) to study the enhancement in SFR as a function of projected galaxy separation. We apply two-point projected correlation function techniques, which we augment with morphologically selected very close pairs (separation