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MDPI, International Journal of Molecular Sciences, 6(13), p. 7260-7270, 2012

DOI: 10.3390/ijms13067260

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Evaluation of the Antioxidant Capacity of Synthesized Coumarins

Journal article published in 2012 by Damiana R. Vianna, Alessandra da Rocha, Gilsane von Poser, Guilherme Bubols, Gabriela Meirelles, Bárbara V. Silva, Maurício Lanznaster ORCID, José Maria Monserrat ORCID, Solange Cristina Garcia, Vera Lucia Eifler-Lima
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH(•)) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.