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Ferrata Storti Foundation, Haematologica, 7(97), p. 1115-1116

DOI: 10.3324/haematol.2012.065235

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Activation state of platelets in experimental severe hemophilia A

Journal article published in 2012 by Maud Teyssandier, Sandrine Delignat, Julie Rayes, Marijke Bryckaert ORCID, Martine Jandrot-Perrus ORCID, Srini V. Kaveri, Sébastien Lacroix-Desmazes
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In a paper recently published in haematologica in 2011, van Bladel et al. found that the state of activation of platelets is up-regulated in patients with severe hemophilia A, as compared to patients with mild/moderate hemophilia A and to healthy donors. An earlier report had however failed to find signs of enhanced platelet pre-activation in patients with severe hemophilia A (Grunewald et al, Platelets 2002).We compared the states of activation and responsiveness of platelets from wild-type mice and from FVIII-deficient mice, an experimental model of severe hemophilia A. Our results indicate that the absence of pro-coagulant FVIII in un-manipulated adult animals is associated neither with alterations in the activation status of circulating platelets nor with their ability to be activated.