In the title solvate, C₄₇H₃₇N₃O₃·C₄H₈O, the cyclohexane ring adopts a chair conformation and the plane through its near coplanar atoms forms dihedral angles of 82.58 (7), 89.27 (7), 60.30 (8), 54.54 (7) and 72.03 (7)°, respectively, with the three pyridine rings and the two attached benzene rings. The rings of the biphenyl units are twisted from each other, making dihedral angles of 35.27 (7) and 45.41 (7)°. All the rings are in equatorial orientations in the cyclohexane ring, except for the C=O-bonded pyridine ring in position 1, which is axial. Intramolecular O—H...N and C—H...O hydrogen bonds form one S(5) and three S(6) ring motifs. In the crystal, molecules are linked via C—H...O hydrogen bonds into a chain along the c axis. The crystal structure also features weak C—H...π interactions and aromatic π–π stacking [centroid–centroid distances = 3.5856 (10) and 3.7090 (9) Å].