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American Society for Microbiology, Infection and Immunity, 1(71), p. 546-549, 2003

DOI: 10.1128/iai.71.1.546-549.2003

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MprF-Mediated Lysinylation of Phospholipids in Staphylococcus aureus Leads to Protection against Oxygen-Independent Neutrophil Killing

Journal article published in 2003 by Sascha A. Kristian, Manuela Dürr, Jos A. G. Van Strijp ORCID, Birgid Neumeister, Andreas Peschel
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Staphylococcus aureus achieves resistance to defensins and similar cationic antimicrobial peptides (CAMPs) by modifying anionic membrane lipids via MprF with l -lysine, which leads to repulsion of these host defense molecules. S. aureus Δ mprF , which lacks the modification, was very efficiently killed by neutrophil defensins and CAMP-producing leukocytes, even when oxygen-dependent killing was disrupted, but was as susceptible as wild-type bacteria to inactivation by myeloperoxidase or human monocytes lacking defensins. These results demonstrate the impact and specificity of MprF-mediated CAMP resistance and underscore the role of defensin-like peptides in innate host defense.