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Cell Press, Cancer Cell, 5(21), p. 597-598, 2012

DOI: 10.1016/j.ccr.2012.04.034

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SMIP-016 in Action: CD37 as a Death Receptor

Journal article published in 2012 by Lei Jin ORCID, John C. Cambier
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

CD37 is a tetraspannin that triggers cell death and is a potential therapeutic target in cancers. In this issue of Cancer Cell, Lapalombella et al. show that CD37 is tyrosine phosphorylated following engagement by a bivalent engineered antibody fragment that binds CD37 and activates both SHP-1-dependent apoptotic signaling and PI3K-AKT-mediated survival signaling.