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American Academy of Pediatrics, Pediatrics, 1(129), p. e199-e203, 2012

DOI: 10.1542/peds.2010-2739

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Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review

Journal article published in 2011 by Sandrine Leroy, Despina Moshous, Olivier Cassar, Yves Reguerre, Minji Byun, Vincent Pedergnana, Danielle Canioni, Antoine Gessain, Eric Oksenhendler, Claire Fieschi, Nizar Mahlaoui, Jean-Pierre Rivière, Rose-Marie Herbigneaux, Matthias Muszlak, Jean-Pierre Arnaud and other authors.
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This paper is available in a repository.

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Abstract

Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.