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Elsevier, Neuropharmacology, (77), p. 350-357, 2014

DOI: 10.1016/j.neuropharm.2013.10.009

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Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress☆

Journal article published in 2014 by Nicoleta Moisoi, Valentina Fedele, Jennifer Edwards, L. Miguel Martins ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Parkinson's disease (PD) shows a complex etiology, where both genetic and environmental factors contribute to initiation and advance of pathology. Mitochondrial dysfunction and mutation of genes implicated in mitochondria quality control are recognized contributors to etiopathology and progression of PD. Here we report the development and characterization of a genetic mouse model of PD with a combined etiology comprising: 1) induction of mitochondrial stress achieved through the expression of a mitochondrial matrix protein that accumulates in an unfolded state and 2) deletion of PINK1 gene. Using this model we address the role of PINK1 in mitochondrial quality control and disease progression.