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National Academy of Sciences, Proceedings of the National Academy of Sciences, 44(109), p. 17880-17885, 2012

DOI: 10.1073/pnas.1206684109

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Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Journal article published in 2012 by Simone Schleede, Ali Ö. Yildirim, Felix G. Meinel ORCID, Martin Bech, Julia Herzen ORCID, Klaus Achterhold, Guillaume Potdevin, Andreas Malecki, Silvia Adam-Neumair, Sven F. Thieme, Fabian Bamberg, Konstantin Nikolaou, Alexander Bohla, A. O. Yildirim, Roderick Loewen and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.