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National Academy of Sciences, Proceedings of the National Academy of Sciences, 40(110), 2013

DOI: 10.1073/pnas.1311711110

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Dendritic growth gated by a steroid hormone receptor underlies increases in activity in the developing Drosophila locomotor system

Journal article published in 2013 by Maarten F. Zwart, Owen Randlett, Jan Felix Evers ORCID, Matthias Landgraf
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Why do bigger animals have bigger brains, and how do they get them? We find in Drosophila larvae that motoneuron dendrites, the branched structures receiving information from other neurons, grow as the animal gets bigger, and that this is regulated on a cell-by-cell basis by a specific isoform of a steroid hormone receptor, whose functions were unknown. As these dendrites enlarge, they form more connections with presynaptic partners, leading to greater levels of neuronal activity. We propose that these nerve cells increase their activity to compensate for the demands of a bigger body.