Published in
American Society of Hematology, Blood Advances, 5(2), p. 492-504, 2018
DOI: 10.1182/bloodadvances.2017010348
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IMiD compounds affect CD34 + cell fate and maturation via CRBN-induced IKZF1 degradation
Journal article published in 2018 by
Shirong Li 
,
Jing Fu ,
Hui Wang,
Huihui Ma,
Xiaoming Xu,
Yong-Guang Yang,
Shixian Deng,
Markus Y. Mapara,
Suzanne Lentzsch
,
Jing Fu ,
Hui Wang,
Huihui Ma,
Xiaoming Xu,
Yong-Guang Yang,
Shixian Deng,
Markus Y. Mapara,
Suzanne Lentzsch
This paper is made freely available by the publisher.
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Abstract
Key Points IMiD compounds cause selective ubiquitination and degradation of IKZF1 in CD34+ cells by the CRBN E3 ubiquitin ligase. Loss of IKZF1 is associated with a decrease of PU.1, critical for the development and maturation of neutrophils.