The Cancer Genome Atlas Pan-Cancer Analysis Project

Wu, Chang-Jiun; Weinstein, John N.; Wu, Chia-Chin; Wu, Junyuan; Collisson, Eric A.; Shaw, K. R. M.; Wu, J.; Mills, Gordon B.; Wu, Hsin-Ta; Chang, Kyle; Xi, Ruibin; Ozenberger, Brad A.; Davis, Caleb; Wheeler, David; Wu, H.-T.; Donehower, Lawrence; Creighton, Chad J.; Drummond, Jennifer; Todd Auman, J.; Ellrott, Kyle; Van Lehmann, Kjong; Ally, Adrian; Van't Veer, Laura; Balasundaram, Miruna; Birol, Inanc; Sander, Chris; Butterfield, Yaron S. N.; Holt, Robert A.; Jones, Steven J. M.; Chu, Andy; Stuart, Joshua M.; Guin, Ranabir; Lee, Darlene; Chuah, Eric; Hirst, Martin; Li, Haiyan I.; Chun, Hye-Jung E.; Marra, Marco A.; Hirst, Carrie; Dhalla, Noreen; Mayo, Michael; Moore, Richard A.; Robertson, A. Gordon; Mungall, Andrew J.; Tam, Angela; Schein, Jacqueline E.; Sipahimalani, Payal; Thiessen, Nina; Varhol, Richard J.; Beroukhim, Rameen; Jung, Joonil; Meyerson, Matthew; Bhatt, Ami S.; Ojesina, Akinyemi I.; Zack, Travis; Brooks, Angela N.; Pedamallu, Chandra Sekhar; Gabriel, Stacey B.; Cherniack, Andrew D.; Saksena, Gordon; Helman, Elena; Schumacher, Steven E.; Tabak, Barbara; Freeman, Samuel S.; Lander, Eric S.; Kucherlapati, Raju; Lee, Semin; Shaw, Kenna M.; Lee, Eunjung; Shaw, Kenna R. Mills; Zou, Lihua; Hadjipanayis, Angela; Luquette, Lovelace J.; Weisenberger, Daniel J.; Haseley, Psalm; Yang, Yang; Bristow, Christopher A.; Xu, Andrew W.; Mahadeshwar, Harshad S.; Pantazi, Angeliki; Parfenov, Michael; Zhang, Jianhua; Zeng, Dong; Protopopov, Alexei; Park, Peter J.; Ren, Xiaojia; Santoso, Netty; Seidman, Jonathan; Mose, Lisle E.; Simons, Janae V.; Tang, Jiabin; Seth, Sahil; Xi, Liu; Song, Xingzhi; Soloway, Mathew G.; Zhang, Hailei; Zheng, Siyuan; Triche, Timothy; Laird, Peter W.; Singer,; Rhie, Suhn K.; Shen, Hui; Herman, James G.; Wang, Min; Wilkerson, Matthew D.; Jones, Corbin D.; Yang, Da; Shaw, Kenna R.; Zhang, Wei; Hinoue, Toshinori; Baylin, Stephen B.; Sougnez, Carrie; Zhao, Wei; Meng, Shaowu; Berman, Benjamin P.; Auman, J. Todd; Bootwalla, Moiz S.; Parker, Joel S.; Mieczkowski, Piotr A.; Danilova, Ludmila; Kalra, Divya; Balu, Saianand; Wu, C.-J.; Kovar, Christie; Buda, Elizabeth; Wu, C.-C.; Perou, Charles M.; Lewis, Lora; Tan, Donghui; Hoadley, Katherine A.; Morgan, Margaret; Roach, Jeffrey; Fan, Cheng; Zhu, Jing; Morton, Donna; Carter, Scott L.; Getz, Gad; Muzny, Donna; Cibulskis, Kristian; Shi, Yan; Veluvolu, Umadevi; Reid, Jeffrey; Chin, Lynda; Silva, Grace O.; Gibbs, Richard; Waring, Scot; Gunaratne, Preethi; Kim, Jaegil; Han, Yi; Voet, Doug; Wong, Andrew; Lawrence, Michael S.; Lin, Pei; Yao, Jun; Dinh, Huyen; Xi, R.; Yao, Rong; Liu, Yingchun; Stojanov, Petar; Noble, Michael S.; Doddapaneni, Harsha Vardhan; Yoshihara, Kosuke; Hoyle, Alan P.; Yang, L.; Yuan, Yuan; Zhang, Nianxiang; Jeffreys, Stuart R.; Yung, Alfred K.; Stewart, Chip; Bodenheimer, Tom; Hayes, D. Neil; Zmuda, Erik; Gehlenborg, Nils; Iype, Lisa; Thorsson, Vesteinn; Knijnenburg, Theo; Heiman, David I.; Cho, Juok; Dicara, Daniel; Kramer, Roger; Frazer, Scott; Kreisberg, Richard; Leinonen, Kalle; Yang, Liming; Lin, Jake; Reynolds, Sheila M.; Liu, Yuexin; Bernard, Brady; Rovira, Hector; Bressler, Ryan; Eakin, Andrea; Yang, Lixing; Yau, Christina; Shmulevich, Ilya; Ju, Zhenlin; Su, Xiaoping; Amin, Samirkumar; Kim, Hoon; Verhaak, Roeland; Lerner, Seth; Wang, Wenyi; Li, Jun; Yang, Tai-Hsien Ou; Akbani, Rehan; Liang, Han; Liu, Wenbin; Aldape, Kenneth; Baggerly, Keith A.; Han, Leng; Lorenzi, Philip L.; Broom, Bradley; Herbrich, Shelley M.; Lu, Yiling; Casasent, Tod D.; Cleland, James; Yang, Y.; Miller, Martin L.; Melott, James; Nguyen, Lam; Dodda, Deepti; Edgerton, Mary; Neil Hayes, D.; Ryan, Michael; Kane, David W.; Wendl, Michael C.; Wilson, Richard K.; Zhang, Qunyuan; Wylie, Todd; Ladanyi, Marc; Miller, Michael L.; Rätsch, Gunnar; Ramirez, Ricardo; Shen, Ronglai; Aksoy, B. Arman; Jacobsen, Anders; Spellman, Paul; Ciriello, Giovanni; Gao, Jianjiong; Kahles, Andre; Dresdner, Gideon; Fei, Suzanne; Ma, Singer; Miller, M.; Gross, Benjamin; Swatloski, Teresa; Ng, Sam; Paull, Evan; Lee, William; Goldman, Mary; Uzunangelov, Vladislav; Benz, Christopher; Haussler, David; Radenbaugh, Amie; Waltman, Peter; Carlin, Daniel; Lehmann, Kjong-Van; Salama, Sofie; Onur Sumer, S.; Sokolov, Artem; Sanchez, Jose; Wise, Lisa; Cline, Melisssa; Craft, Brian; Reva, Boris; Sumer, S. Onur; Schultz, Nikolaus; Sun, Yichao; Senbabaoglu, Yasin; Zhang, Jiashan; Kalicki-Veizer, Joelle; Weinhold, Nils; Sinha, Rileen; Taylor, Barry S.; Kanchi, Krishna-Latha; Wolf, Denise; Kandoth, Cyriac; Koboldt, Daniel C.; Mills Shaw, Kenna R.; Walker, Jason; Larson, David E.; Abbott, Scott; Ley, Timothy J.; Fronick, Catrina C.; Wallis, John W.; Lin, Ling; Xia, Zheng; Ramirez, R.; Lu, Charles; Abbott, Rachel; Magrini, Vincent J.; Dees, Nathan D.; Fulton, Robert; Mardis, Elaine R.; Hamilton, M.; Delehaunty, Kim; Fulton, Lucinda L.; Ding, Li; McLellan, Michael D.; Dooling, David J.; Eldred, Jim M.; Pohl, Craig; McMichael, Joshua F.; Wan, Yunhu; Miller, Christopher A.; O'Laughlin, Michelle; Schmidt, Heather; Smith, Scott M.; Jensen, Mark A.; Kahn, Ari; Pihl, Todd; Pot, David; Burton, Robert; Gordon Robertson, A.; Frick, Jessica; Leraas, Kristen M.; Gastier Foster, Julie M.; Hamilton, Stanley R.; Lichtenberg, Tara M.; Black, Aaron D.; McAllister, Cynthia; Harper, Hollie A.; Tarnuzzer, Roy; Ramirez, Nilsa C.; Bowen, Jay; Helsel, Carmen; Wang, Zhining; Sharpe, Samantha; Levine, Douglas A.; Vandin, Fabio; Chanock, Stephen J.; Sheth, Margi; Ratsch, G.; Davidsen, Tanja; Sofia, Heidi; Demchok, John A.; Staudt, Louis; Vaske, Charles J.; Eley, Greg; Felau, Ina; Omberg, Larsson; Veer, Laura Van't; Margolin, Adam; Raphael, Benjamin J.; Tamborero, David; Leiserson, Mark D. M.; Benz, Stephen C.; Noushmehr, Houtan; Yang, T.-H. O.; Lopez-Bigas, Nuria; Anastassiou, Dimitris; Gonzalez-Perez, Abel; Li, Wei; Hamilton, Mark; Przytycka, Teresa; Cho, Dong-Yeon; McGuire, Sean; Nelander, Sven; Johansson, Patrik; Jörnsten, Rebecka; Kling, Teresia; Arman Aksoy, B.

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Joshua Stuart
Wu et al., 2013

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Nature Research, Nature Genetics, 10(45), p. 1113-1120, 2013

DOI: 10.1038/ng.2764

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@article{Wu2013,
  abstract = {Cancer can take hundreds of different forms depending on the location, cell of origin and spectrum of genomic alterations that promote oncogenesis and affect therapeutic response. Although many genomic events with direct phenotypic impact have been identified, much of the complex molecular landscape remains incompletely charted for most cancer lineages. For that reason, The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumours to discover molecular aberrations at the DNA, RNA, protein, and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences, and emergent themes across tumour lineages. The Pan-Cancer initiative compares the first twelve tumour types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumour types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.},
  author = {Wu, Chang-Jiun and Weinstein, John N. and Wu, Chia-Chin and Wu, Junyuan and Collisson, Eric A. and Shaw, K. R. M. and Wu, J. and Mills, Gordon B. and Wu, Hsin-Ta and Chang, Kyle and Xi, Ruibin and Ozenberger, Brad A. and Davis, Caleb and Wheeler, David and Wu, H.-T. and Donehower, Lawrence and Creighton, Chad J. and Drummond, Jennifer and Todd Auman, J. and Ellrott, Kyle and Van Lehmann, Kjong and Ally, Adrian and Van't Veer, Laura and Balasundaram, Miruna and Birol, Inanc and Sander, Chris and Butterfield, Yaron S. N. and Holt, Robert A. and Jones, Steven J. M. and Chu, Andy and Stuart, Joshua M. and Guin, Ranabir and Lee, Darlene and Chuah, Eric and Hirst, Martin and Li, Haiyan I. and Chun, Hye-Jung E. and Marra, Marco A. and Hirst, Carrie and Dhalla, Noreen and Mayo, Michael and Moore, Richard A. and Robertson, A. Gordon and Mungall, Andrew J. and Tam, Angela and Schein, Jacqueline E. and Sipahimalani, Payal and Thiessen, Nina and Varhol, Richard J. and Beroukhim, Rameen and Jung, Joonil and Meyerson, Matthew and Bhatt, Ami S. and Ojesina, Akinyemi I. and Zack, Travis and Brooks, Angela N. and Pedamallu, Chandra Sekhar and Gabriel, Stacey B. and Cherniack, Andrew D. and Saksena, Gordon and Helman, Elena and Schumacher, Steven E. and Tabak, Barbara and Freeman, Samuel S. and Lander, Eric S. and Kucherlapati, Raju and Lee, Semin and Shaw, Kenna M. and Lee, Eunjung and Shaw, Kenna R. Mills and Zou, Lihua and Hadjipanayis, Angela and Luquette, Lovelace J. and Weisenberger, Daniel J. and Haseley, Psalm and Yang, Yang and Bristow, Christopher A. and Xu, Andrew W. and Mahadeshwar, Harshad S. and Pantazi, Angeliki and Parfenov, Michael and Zhang, Jianhua and Zeng, Dong and Protopopov, Alexei and Park, Peter J. and Ren, Xiaojia and Santoso, Netty and Seidman, Jonathan and Mose, Lisle E. and Simons, Janae V. and Tang, Jiabin and Seth, Sahil and Xi, Liu and Song, Xingzhi and Soloway, Mathew G. and Zhang, Hailei and Zheng, Siyuan and Triche, Timothy and Laird, Peter W. and Singer,  and Rhie, Suhn K. and Shen, Hui and Herman, James G. and Wang, Min and Wilkerson, Matthew D. and Jones, Corbin D. and Yang, Da and Shaw, Kenna R. and Zhang, Wei and Hinoue, Toshinori and Baylin, Stephen B. and Sougnez, Carrie and Zhao, Wei and Meng, Shaowu and Berman, Benjamin P. and Auman, J. Todd and Bootwalla, Moiz S. and Parker, Joel S. and Mieczkowski, Piotr A. and Danilova, Ludmila and Kalra, Divya and Balu, Saianand and Wu, C.-J. and Kovar, Christie and Buda, Elizabeth and Wu, C.-C. and Perou, Charles M. and Lewis, Lora and Tan, Donghui and Hoadley, Katherine A. and Morgan, Margaret and Roach, Jeffrey and Fan, Cheng and Zhu, Jing and Morton, Donna and Carter, Scott L. and Getz, Gad and Muzny, Donna and Cibulskis, Kristian and Shi, Yan and Veluvolu, Umadevi and Reid, Jeffrey and Chin, Lynda and Silva, Grace O. and Gibbs, Richard and Waring, Scot and Gunaratne, Preethi and Kim, Jaegil and Han, Yi and Voet, Doug and Wong, Andrew and Lawrence, Michael S. and Lin, Pei and Yao, Jun and Dinh, Huyen and Xi, R. and Yao, Rong and Liu, Yingchun and Stojanov, Petar and Noble, Michael S. and Doddapaneni, Harsha Vardhan and Yoshihara, Kosuke and Hoyle, Alan P. and Yang, L. and Yuan, Yuan and Zhang, Nianxiang and Jeffreys, Stuart R. and Yung, Alfred K. and Stewart, Chip and Bodenheimer, Tom and Hayes, D. Neil and Zmuda, Erik and Gehlenborg, Nils and Iype, Lisa and Thorsson, Vesteinn and Knijnenburg, Theo and Heiman, David I. and Cho, Juok and Dicara, Daniel and Kramer, Roger and Frazer, Scott and Kreisberg, Richard and Leinonen, Kalle and Yang, Liming and Lin, Jake and Reynolds, Sheila M. and Liu, Yuexin and Bernard, Brady and Rovira, Hector and Bressler, Ryan and Eakin, Andrea and Yang, Lixing and Yau, Christina and Shmulevich, Ilya and Ju, Zhenlin and Su, Xiaoping and Amin, Samirkumar and Kim, Hoon and Verhaak, Roeland and Lerner, Seth and Wang, Wenyi and Li, Jun and Yang, Tai-Hsien Ou and Akbani, Rehan and Liang, Han and Liu, Wenbin and Aldape, Kenneth and Baggerly, Keith A. and Han, Leng and Lorenzi, Philip L. and Broom, Bradley and Herbrich, Shelley M. and Lu, Yiling and Casasent, Tod D. and Cleland, James and Yang, Y. and Miller, Martin L. and Melott, James and Nguyen, Lam and Dodda, Deepti and Edgerton, Mary and Neil Hayes, D. and Ryan, Michael and Kane, David W. and Wendl, Michael C. and Wilson, Richard K. and Zhang, Qunyuan and Wylie, Todd and Ladanyi, Marc and Miller, Michael L. and Rätsch, Gunnar and Ramirez, Ricardo and Shen, Ronglai and Aksoy, B. Arman and Jacobsen, Anders and Spellman, Paul and Ciriello, Giovanni and Gao, Jianjiong and Kahles, Andre and Dresdner, Gideon and Fei, Suzanne and Ma, Singer and Miller, M. and Gross, Benjamin and Swatloski, Teresa and Ng, Sam and Paull, Evan and Lee, William and Goldman, Mary and Uzunangelov, Vladislav and Benz, Christopher and Haussler, David and Radenbaugh, Amie and Waltman, Peter and Carlin, Daniel and Lehmann, Kjong-Van and Salama, Sofie and Onur Sumer, S. and Sokolov, Artem and Sanchez, Jose and Wise, Lisa and Cline, Melisssa and Craft, Brian and Reva, Boris and Sumer, S. Onur and Schultz, Nikolaus and Sun, Yichao and Senbabaoglu, Yasin and Zhang, Jiashan and Kalicki-Veizer, Joelle and Weinhold, Nils and Sinha, Rileen and Taylor, Barry S. and Kanchi, Krishna-Latha and Wolf, Denise and Kandoth, Cyriac and Koboldt, Daniel C. and Mills Shaw, Kenna R. and Walker, Jason and Larson, David E. and Abbott, Scott and Ley, Timothy J. and Fronick, Catrina C. and Wallis, John W. and Lin, Ling and Xia, Zheng and Ramirez, R. and Lu, Charles and Abbott, Rachel and Magrini, Vincent J. and Dees, Nathan D. and Fulton, Robert and Mardis, Elaine R. and Hamilton, M. and Delehaunty, Kim and Fulton, Lucinda L. and Ding, Li and McLellan, Michael D. and Dooling, David J. and Eldred, Jim M. and Pohl, Craig and McMichael, Joshua F. and Wan, Yunhu and Miller, Christopher A. and O'Laughlin, Michelle and Schmidt, Heather and Smith, Scott M. and Jensen, Mark A. and Kahn, Ari and Pihl, Todd and Pot, David and Burton, Robert and Gordon Robertson, A. and Frick, Jessica and Leraas, Kristen M. and Gastier Foster, Julie M. and Hamilton, Stanley R. and Lichtenberg, Tara M. and Black, Aaron D. and McAllister, Cynthia and Harper, Hollie A. and Tarnuzzer, Roy and Ramirez, Nilsa C. and Bowen, Jay and Helsel, Carmen and Wang, Zhining and Sharpe, Samantha and Levine, Douglas A. and Vandin, Fabio and Chanock, Stephen J. and Sheth, Margi and Ratsch, G. and Davidsen, Tanja and Sofia, Heidi and Demchok, John A. and Staudt, Louis and Vaske, Charles J. and Eley, Greg and Felau, Ina and Omberg, Larsson and Veer, Laura Van't and Margolin, Adam and Raphael, Benjamin J. and Tamborero, David and Leiserson, Mark D. M. and Benz, Stephen C. and Noushmehr, Houtan and Yang, T.-H. O. and Lopez-Bigas, Nuria and Anastassiou, Dimitris and Gonzalez-Perez, Abel and Li, Wei and Hamilton, Mark and Przytycka, Teresa and Cho, Dong-Yeon and McGuire, Sean and Nelander, Sven and Johansson, Patrik and Jörnsten, Rebecka and Kling, Teresia and Arman Aksoy, B.},
  doi = {10.1038/ng.2764},
  journal = {Nature Genetics},
  month = {sep},
  pages = {1113-1120},
  title = {The Cancer Genome Atlas Pan-Cancer Analysis Project},
  url = {http://www.nature.com/articles/ng.2764.pdf},
  volume = {45},
  year = {2013}
}

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The Cancer Genome Atlas Pan-Cancer Analysis Project

Journal article published in 2013 by Chang-Jiun Wu, John N. Weinstein, Chia-Chin Wu, Junyuan Wu, Eric A. Collisson, K. R. M. Shaw, J. Wu, Gordon B. Mills, Hsin-Ta Wu, Kyle Chang, Ruibin Xi, Brad A. Ozenberger, Caleb Davis, David Wheeler, H.-T. Wu and other authors. Chang-Jiun Wu, John N. Weinstein, Chia-Chin Wu, Junyuan Wu, Eric A. Collisson, K. R. M. Shaw, J. Wu, Gordon B. Mills, Hsin-Ta Wu, Kyle Chang, Ruibin Xi, Brad A. Ozenberger, Caleb Davis, David Wheeler, H.-T. Wu, Lawrence Donehower, Chad J. Creighton, Jennifer Drummond, J. Todd Auman, Kyle Ellrott, Kjong Van Lehmann, Adrian Ally, Laura Van't Veer, Miruna Balasundaram, Inanc Birol, Chris Sander, Yaron S. N. Butterfield, Robert A. Holt, Steven J. M. Jones, Andy Chu, Joshua M. Stuart

, Ranabir Guin, Darlene Lee, Eric Chuah, Martin Hirst, Haiyan I. Li, Hye-Jung E. Chun, Marco A. Marra, Carrie Hirst, Noreen Dhalla, Michael Mayo, Richard A. Moore, A. Gordon Robertson, Andrew J. Mungall

, Angela Tam, Jacqueline E. Schein, Payal Sipahimalani, Nina Thiessen, Richard J. Varhol, Rameen Beroukhim, Joonil Jung, Matthew Meyerson, Ami S. Bhatt, Akinyemi I. Ojesina, Travis Zack, Angela N. Brooks, Chandra Sekhar Pedamallu, Stacey B. Gabriel, Andrew D. Cherniack, Gordon Saksena, Elena Helman, Steven E. Schumacher, Barbara Tabak, Samuel S. Freeman

, Eric S. Lander, Raju Kucherlapati, Semin Lee, Kenna M. Shaw, Eunjung Lee, Kenna R. Mills Shaw, Lihua Zou, Angela Hadjipanayis, Lovelace J. Luquette, Daniel J. Weisenberger, Psalm Haseley, Yang Yang, Christopher A. Bristow, Andrew W. Xu, Harshad S. Mahadeshwar, Angeliki Pantazi, Michael Parfenov, Jianhua Zhang, Dong Zeng, Alexei Protopopov, Peter J. Park, Xiaojia Ren, Netty Santoso, Jonathan Seidman, Lisle E. Mose, Janae V. Simons, Jiabin Tang, Sahil Seth, Liu Xi, Xingzhi Song, Mathew G. Soloway, Hailei Zhang, Siyuan Zheng, Timothy Triche, Peter W. Laird, Singer, Suhn K. Rhie, Hui Shen, James G. Herman, Min Wang, Matthew D. Wilkerson, Corbin D. Jones, Da Yang

, Kenna R. Shaw, Wei Zhang, Toshinori Hinoue, Stephen B. Baylin, Carrie Sougnez, Wei Zhao, Shaowu Meng, Benjamin P. Berman, J. Todd Auman, Moiz S. Bootwalla, Joel S. Parker, Piotr A. Mieczkowski, Ludmila Danilova, Divya Kalra, Saianand Balu, C.-J. Wu, Christie Kovar, Elizabeth Buda, C.-C. Wu, Charles M. Perou, Lora Lewis, Donghui Tan, Katherine A. Hoadley

, Margaret Morgan, Jeffrey Roach, Cheng Fan, Jing Zhu, Donna Morton, Scott L. Carter, Gad Getz, Donna Muzny, Kristian Cibulskis, Yan Shi, Umadevi Veluvolu, Jeffrey Reid, Lynda Chin, Grace O. Silva, Richard Gibbs, Scot Waring, Preethi Gunaratne, Jaegil Kim, Yi Han, Doug Voet, Andrew Wong, Michael S. Lawrence, Pei Lin, Jun Yao, Huyen Dinh, R. Xi, Rong Yao, Yingchun Liu, Petar Stojanov, Michael S. Noble, Harsha Vardhan Doddapaneni, Kosuke Yoshihara, Alan P. Hoyle, L. Yang, Yuan Yuan

, Nianxiang Zhang, Stuart R. Jeffreys, Alfred K. Yung, Chip Stewart, Tom Bodenheimer, D. Neil Hayes, Erik Zmuda, Nils Gehlenborg, Lisa Iype, Vesteinn Thorsson, Theo Knijnenburg, David I. Heiman

, Juok Cho, Daniel Dicara, Roger Kramer, Scott Frazer, Richard Kreisberg, Kalle Leinonen, Liming Yang, Jake Lin, Sheila M. Reynolds, Yuexin Liu, Brady Bernard, Hector Rovira, Ryan Bressler, Andrea Eakin, Lixing Yang, Christina Yau, Ilya Shmulevich, Zhenlin Ju, Xiaoping Su, Samirkumar Amin, Hoon Kim

, Roeland Verhaak, Seth Lerner, Wenyi Wang, Jun Li, Tai-Hsien Ou Yang, Rehan Akbani, Han Liang, Wenbin Liu, Kenneth Aldape, Keith A. Baggerly, Leng Han, Philip L. Lorenzi, Bradley Broom, Shelley M. Herbrich, Yiling Lu, Tod D. Casasent, James Cleland, Y. Yang, Martin L. Miller

, James Melott, Lam Nguyen, Deepti Dodda, Mary Edgerton, D. Neil Hayes, Michael Ryan, David W. Kane, Michael C. Wendl, Richard K. Wilson, Qunyuan Zhang, Todd Wylie, Marc Ladanyi, Michael L. Miller, Gunnar Rätsch, Ricardo Ramirez, Ronglai Shen, B. Arman Aksoy, Anders Jacobsen, Paul Spellman, Giovanni Ciriello, Jianjiong Gao, Andre Kahles, Gideon Dresdner, Suzanne Fei, Singer Ma, M. Miller, Benjamin Gross, Teresa Swatloski, Sam Ng, Evan Paull, William Lee, Mary Goldman, Vladislav Uzunangelov, Christopher Benz, David Haussler, Amie Radenbaugh, Peter Waltman, Daniel Carlin, Kjong-Van Lehmann

, Sofie Salama

, S. Onur Sumer, Artem Sokolov, Jose Sanchez, Lisa Wise, Melisssa Cline, Brian Craft, Boris Reva, S. Onur Sumer, Nikolaus Schultz

, Yichao Sun, Yasin Senbabaoglu, Jiashan Zhang, Joelle Kalicki-Veizer, Nils Weinhold, Rileen Sinha, Barry S. Taylor, Krishna-Latha Kanchi, Denise Wolf, Cyriac Kandoth, Daniel C. Koboldt, Kenna R. Mills Shaw, Jason Walker, David E. Larson, Scott Abbott, Timothy J. Ley, Catrina C. Fronick, John W. Wallis, Ling Lin, Zheng Xia, R. Ramirez, Charles Lu, Rachel Abbott, Vincent J. Magrini, Nathan D. Dees, Robert Fulton, Elaine R. Mardis, M. Hamilton, Kim Delehaunty, Lucinda L. Fulton, Li Ding, Michael D. McLellan, David J. Dooling, Jim M. Eldred, Craig Pohl, Joshua F. McMichael, Yunhu Wan, Christopher A. Miller, Michelle O'Laughlin, Heather Schmidt, Scott M. Smith, Mark A. Jensen, Ari Kahn, Todd Pihl, David Pot, Robert Burton, A. Gordon Robertson, Jessica Frick, Kristen M. Leraas, Julie M. Gastier Foster, Stanley R. Hamilton, Tara M. Lichtenberg, Aaron D. Black, Cynthia McAllister, Hollie A. Harper, Roy Tarnuzzer, Nilsa C. Ramirez, Jay Bowen, Carmen Helsel, Zhining Wang, Samantha Sharpe, Douglas A. Levine, Fabio Vandin, Stephen J. Chanock, Margi Sheth, G. Ratsch, Tanja Davidsen, Heidi Sofia, John A. Demchok, Louis Staudt, Charles J. Vaske, Greg Eley, Ina Felau, Larsson Omberg, Laura Van't Veer, Adam Margolin, Benjamin J. Raphael, David Tamborero, Mark D. M. Leiserson, Stephen C. Benz, Houtan Noushmehr, T.-H. O. Yang, Nuria Lopez-Bigas, Dimitris Anastassiou, Abel Gonzalez-Perez, Wei Li, Mark Hamilton, Teresa Przytycka, Dong-Yeon Cho, Sean McGuire, Sven Nelander, Patrik Johansson, Rebecka Jörnsten, Teresia Kling, B. Arman Aksoy

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Abstract

Cancer can take hundreds of different forms depending on the location, cell of origin and spectrum of genomic alterations that promote oncogenesis and affect therapeutic response. Although many genomic events with direct phenotypic impact have been identified, much of the complex molecular landscape remains incompletely charted for most cancer lineages. For that reason, The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumours to discover molecular aberrations at the DNA, RNA, protein, and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences, and emergent themes across tumour lineages. The Pan-Cancer initiative compares the first twelve tumour types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumour types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.

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The Cancer Genome Atlas Pan-Cancer Analysis Project

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