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Nature Research, Nature Genetics, 10(45), p. 1113-1120, 2013

DOI: 10.1038/ng.2764

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The Cancer Genome Atlas Pan-Cancer Analysis Project

Journal article published in 2013 by Kyle Chang, Wei Zhang, Nianxiang Zhang, David Wheeler, Qunyuan Zhang, Jiashan Zhang, Travis Zack, Ruibin Xi, Andrew W. Xu, Lixing Yang, Dong Zeng, Matthew D. Wilkerson, Junyuan Wu, Wei Zhao, Daniel J. Weisenberger and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cancer can take hundreds of different forms depending on the location, cell of origin and spectrum of genomic alterations that promote oncogenesis and affect therapeutic response. Although many genomic events with direct phenotypic impact have been identified, much of the complex molecular landscape remains incompletely charted for most cancer lineages. For that reason, The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumours to discover molecular aberrations at the DNA, RNA, protein, and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences, and emergent themes across tumour lineages. The Pan-Cancer initiative compares the first twelve tumour types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumour types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.