Published in
American Association for the Advancement of Science, Science Translational Medicine, 431(10), 2018
DOI: 10.1126/scitranslmed.aam8460
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Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia
Journal article published in 2018 by
Lina Benajiba 
,
Florence F. Wagner ,
Arthur J. Campbell ,
Michel Weïwer ,
Joshua R. Sacher ,
Jennifer P. Gale ,
Linda Ross ,
Alexandre Puissant,
Gabriela Alexe ,
Amy Conway ,
Morgan Back,
Yana Pikman ,
Ilene Galinsky ,
Daniel J. DeAngelo ,
Richard M. Stone
and other authors.
,
Florence F. Wagner ,
Arthur J. Campbell ,
Michel Weïwer ,
Joshua R. Sacher ,
Jennifer P. Gale ,
Linda Ross ,
Alexandre Puissant,
Gabriela Alexe ,
Amy Conway ,
Morgan Back,
Yana Pikman ,
Ilene Galinsky ,
Daniel J. DeAngelo ,
Richard M. Stone
and other authors.
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Abstract
Paralog-selective inhibitors of GSK3 kinases were designed by exploiting a single amino acid difference in their ATP-binding domains and studied in AML.