Published in

Elsevier, Cancer Letters, 2(325), p. 175-188, 2012

DOI: 10.1016/j.canlet.2012.06.014

Links

Tools

Export citation

Search in Google Scholar

Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals

Journal article published in 2012 by Inke Lühr, Andreas Friedl, Thorsten Overath, Andreas Tholey, Thomas Kunze, Felix Hilpert, Susanne Sebens, Norbert Arnold ORCID, Frank Rösel, Hans-Heinrich Oberg, Nicolai Maass, Christoph Mundhenke, Walter Jonat, Maret Bauer
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy.