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American Society of Hematology, Blood Advances, 3(2), p. 271-284, 2018

DOI: 10.1182/bloodadvances.2017012781

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C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia

Journal article published in 2018 by Justin Loke, Paulynn Suyin Chin, Peter Keane, Anna Pickin, Salam A. Assi, Anetta Ptasinska, Maria Rosaria Imperato, Peter N. Cockerill, Constanze Bonifer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points C/EBPα directly represses the leukemia maintenance program; however, the pattern of repressed genes is specific for each type of AML. Overexpression of C/EBPα does not globally displace these proteins from their binding sites, but overrides their repressive activity.