Published in
American Society of Hematology, Blood Advances, 3(2), p. 271-284, 2018
DOI: 10.1182/bloodadvances.2017012781
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C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia
Journal article published in 2018 by
Justin Loke 
,
Paulynn Suyin Chin,
Peter Keane,
Anna Pickin,
Salam A. Assi,
Anetta Ptasinska,
Maria Rosaria Imperato,
Peter N. Cockerill,
Constanze Bonifer
,
Paulynn Suyin Chin,
Peter Keane,
Anna Pickin,
Salam A. Assi,
Anetta Ptasinska,
Maria Rosaria Imperato,
Peter N. Cockerill,
Constanze Bonifer
This paper is made freely available by the publisher.
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Abstract
Key Points C/EBPα directly represses the leukemia maintenance program; however, the pattern of repressed genes is specific for each type of AML. Overexpression of C/EBPα does not globally displace these proteins from their binding sites, but overrides their repressive activity.